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Cyclosporine Nephrotoxicity Without Major Organ Transplantation

N. STANLEY NAHMAN Jr, M.D.; FERNANDO G. COSIO, M.D.; SETH KOLKIN, M.D.; JERRY R. MENDELL, M.D.; and HARI M. SHARMA, M.D.
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▸Requests for reprints should be addressed to N. Stanley Nahman, Jr., M.D.; Department of Medicine, The Ohio State University Medical Center, Room N-210, Means Hall; Columbus, OH 43210.


The Ohio State University, Columbus, Ohio


Ann Intern Med. 1987;106(3):400-402. doi:10.7326/0003-4819-106-3-400
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This excerpt has been provided in the absence of an abstract.

Cyclosporine is an immunosuppressant used primarily in transplantation (1) and more recently in the therapy of autoimmune disease (2, 3). Nephrotoxicity is a well-recognized complication of cyclosporine and includes functional and anatomical damage (1-6). We report the cases of two patients given cyclosporine for immunologic diseases other than major organ transplantation. Both patients developed irreversible renal functional impairment and had renal biopsy findings consistent with chronic cyclosporine nephrotoxicity.

Patient 1: A 25-year-old white woman with a history of congenital glaucoma and recurrent cataracts required several corneal transplants. In July 1984, after bilateral corneal graft placement, the patient was given cyclosporine,

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