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Removal of Toxic Levels of N-Acetylprocainamide with Continuous Arteriovenous Hemofiltration or Continuous Arteriovenous Hemodiafiltration

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Presented in part at the International Workshop on Hemofiltration, October 1985, New York, New York.

▸Requests for reprints should be addressed to Douglass T. Domoto, M.D.; Department of Internal Medicine, St. Louis University Medical Center, 1325 South Grand Boulevard; St. Louis, MO 63104.

St. Louis, Missouri

© 1987 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1987;106(4):550-552. doi:10.7326/0003-4819-106-4-550
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Two patients with renal failure developed N-acetylprocainamide toxicity while receiving procainamide. Treatment consisted of continuous arteriovenous hemofiltration in one and hemodialysis followed by continuous arteriovenous hemodiafiltration in the other. The efficacy of these treatments was compared with the efficacy of three-times-weekly hemodialysis as used in two patients on chronic hemodialysis who had elevated N-acetylprocainamide levels. Continuous methods produced a more rapid reduction in N-acetylprocainamide levels than intermittent hemodialysis.





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