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Cocaine Use and the Risk for Endocarditis in Intravenous Drug Users

HENRY F. CHAMBERS, M.D.; D. LYNN MORRIS, M.D.; MARTIN G. TÄUBER, M.D.; and GUNNARD MODIN, B.S.
[+] Article and Author Information

▸Requests for reprints should be addressed to Henry F. Chambers, M.D.; 5H22 Department of Medicine, San Francisco General Hospital; San Francisco, CA 94110.


San Francisco, California


© 1987 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1987;106(6):833-836. doi:10.7326/0003-4819-106-6-833
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Endocarditis is a relatively frequent infection in intravenous drug users. We compared features in the cases of 102 patients with those in intravenous drug users with other causes of fever to identify risk factors predictive of endocarditis. Logistic regression analysis showed cocaine use to be strongly associated with endocarditis. This special risk involving cocaine use has not been reported previously; the explanation for it may provide insight into the pathogenesis of endocarditis.

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