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Cyclosporine May Alleviate B Symptoms and Induce a Remission of Heavily Pretreated Hodgkin Disease: A Preliminary Report

MATJAž ZWITTER, M.D., M.SC.; JOžE DRINOVEC, Ph.D.; MIRKO DUBRAVČIĆ, M.D.; ALENKA VODNIK, M.D.; JELKA PETRIČ-GRABNAR, M.D.; MAJDA DOLNIČAR, M.D.; MIODRAG KONSTANTINOVIĆ, Ph.D.; and žARKA žEMVA, M.SC.
[+] Article and Author Information

Grant support: in part by a grant from the Research Council of Slovenia.

▸Requests for reprints should be addressed to MatjaŽ Zwitter, M.D. M.Sc; Institute of Oncology, Zaloska 2; 61105 Ljubljana, Yugoslavia.


Institute of Oncology and University Clinical Center, Ljubljana; and Military Hospital and Clinical Center for Oncology and Radiotherapy, Split, Yugoslavia


Ann Intern Med. 1987;106(6):843-844. doi:10.7326/0003-4819-106-6-843
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This excerpt has been provided in the absence of an abstract.

The outlook for patients with Hodgkin disease in relapse after receiving several combinations of cytotoxic drugs is still unfavorable. Our preliminary experience with cyclosporine indicates that the introduction of a new drug and a new therapeutic approach deserves further attention in Hodgkin disease, and possibly in other lymphoproliferative disorders.

Ten patients with Hodgkin disease who had a biopsy-proven relapse after first- and second-line chemotherapy participated in the study (Table 1). All patients had measurable extranodal disease with B symptoms, normal renal function, and gave informed consent for a new treatment.

Cyclosporine was taken orally twice daily, diluted in milk or

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