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Pancreatitis Associated with Isotretinoin-lnduced Hypertriglyceridemia

WILLIAM J. FLYNN, M.D.; PAMELA G. FREEMAN, M.D.; and LLOYD G. WICKBOLDT, M.D.
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▸Requests for reprints should be addressed to Pamela G. Freeman, M.D.; 85 West Miller, Suite 405; Orlando, FL 32806.


Orlando Regional Medical Center; Orlando, Florida


Ann Intern Med. 1987;107(1):63. doi:10.7326/0003-4819-107-1-63
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Isotretinoin (Accutane; Roche Laboratories, Nutley New Jersey) is a vitamin A derivative useful in the treatment of skin disorders caused by follicular occlusion. Isotretinoin is most frequently prescribed for recalcitrant nodulocystic acne ( 1 ). Elevation of the serum triglyceride level has been previously reported (2). We report a case of pancreatitis precipitated by hypertriglyceridemia associated with isotretinoin therapy.

A 43-year-old white woman had a 10-year history of nodulocystic acne and hidradenitis suppurativa refractory to oral tetracyclines and topical therapy. Isotretinoin had been instituted at 40 mg orally twice daily (1.0 mg/kg bodyweight · d) after baseline fasting laboratory studies

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