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Predictors of Occult Carbon Monoxide Poisoning in Patients with Headache and Dizziness

PAUL S. HECKERLING, M.D.; JERROLD B. LEIKIN, M.D.; ANDREW MATUREN, Ph.D.; and JAMES T. PERKINS, M.D.
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▸Requests for reprints should be addressed to Paul S. Heckerling, M.D.; Department of Medicine, University of Illinois at Chicago, Box 6998; Chicago, IL 60680.


©1987 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1987;107(2):174-176. doi:10.7326/0003-4819-107-2-174
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Headache and dizziness occur at carboxyhemoglobin levels of greater than 10%. We studied 89 patients with headache or dizziness for evidence of carbon monoxide exposure. The mean carboxyhemoglobin level was 2.87%. Number of cigarettes smoked per day (r = 0.471; p < 0.00002), use of gas kitchen stoves for heating purposes (r = 0.252, p < 0.02), problems with the home heating system (r = 0.278, p < 0.01), and cohabitants with concurrent headache or dizziness (r = 0.427, p < 0.01) correlated with carboxyhemoglobin levels. Multiple regression analysis identified number of cigarettes smoked daily, use of stoves for heat, and concurrently symptomatic cohabitants as significant predictors of carboxyhemoglobin level (F = 13.939 [3, 85]; p < 0.01). Obtaining carboxyhemoglobin levels from patients who used stoves for heat or had similarly affected cohabitants identified 4 of 4 patients with levels greater than 10% (sensitivity, 100%) and excluded 47 of 85 patients with lower levels (specificity, 55.3%). The 4 patients with carboxyhemoglobin levels in excess of 10% may represent occult carbon monoxide poisoning in this population.

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[Carbon monoxide poisoning after smoking from a water pipe]. Ned Tijdschr Geneeskd 2013;157(29):A6201.
Cardiovascular Abnormalities in Carbon Monoxide Poisoning. Am J Ther Published online Feb 10, 2014.;
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