0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Academia and the Profession |

Meta-Analysis in Clinical Research

KRISTAN A. L'ABBÉ, M.Sc.; ALLAN S. DETSKY, M.D., Ph.D.; and KEITH O'ROURKE, M.B.A.
[+] Article and Author Information

Grant support: in part by grant HS-05374-01 from the National Center for Health Services Research and Health Care Technology Assessment, and by the National Health Research and Development Program (Canada) through a National Health Ph.D. fellowship to Dr. L'Abbé and a National Health Research Scholar award to Dr. Detsky.

▸Requests for reprints should be addressed to Kristan A. L'Abbé, M.Sc.; Department of Preventive Medicine and Biostatistics, McMurrich Building, 4th Floor, University of Toronto; Toronto, Ontario, Canada M5S 1A8.


Toronto, Ontario, Canada


Ann Intern Med. 1987;107(2):224-233. doi:10.7326/0003-4819-107-2-224
Text Size: A A A

Meta-analysis is the process of combining study results that can be used to draw conclusions about therapeutic effectiveness or to plan new studies. We review important design and statistical issues of this process. The design issues include protocol development, objectives, literature search, publication bias, measures of study outcomes, and quality of the data. The statistical issues include consistency (homogeneity) of study outcomes, and techniques for pooling results from several studies. Guidelines are provided to assess the quality of meta-analyses based on our discussion of the design and statistical issues. Limitations and areas for further development of this approach are discussed; researchers should come to a general agreement on how to conduct meta-analysis. As an explicit strategy for summarizing results, meta-analysis may help clinicians and researchers better understand the findings of clinical studies.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)