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Fulminant Hepatic Failure After Occupational Exposure to 2-Nitropropane

ROBERT HARRISON, M.D., M.P.H.; GIDEON LETZ, M.D., M.P.H.; GARY PASTERNAK, M.D.; and PAUL BLANC, M.D., M.S.P.H.
[+] Article and Author Information

▸Requests for reprints should be addressed to Robert Harrison, M.D.; 400 Parnassus Avenue, Room 405; San Francisco, CA 94143.


San Francisco and Berkeley, California


©1987 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1987;107(4):466-468. doi:10.7326/0003-4819-107-4-466
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Two construction workers became ill after applying an epoxy resin coating containing 2-nitropropane in the confined space of an underground concrete vault. One man died 10 days later from fulminant hepatic failure. The second man recovered but has had persistently elevated serum aminotransferase activity. The serum concentration of 2-nitropropane on admission of the man who died was 13 mg/L, and was 8.5 mg/L in his coworker. The acute toxicity of 2-nitropropane has not been widely appreciated despite previous reports of death due to hepatic failure after exposure to the compound in confined spaces. These cases show the importance of effective education and protective work practices.

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