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Antigen-Specific T-Cell Anergy in Progressive Mycobacterium marinum Infection in Humans

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▸Requests for reprints should be addressed to Raymond J. Dattwyler, M.D.; State University of New York at Stony Brook, Division of Immunology, HSC T16 R040; Stony Brook, NY 11794-8161.

Stony Brook, New York

©1987 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1987;107(5):675-677. doi:10.7326/0003-4819-107-5-675
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The cellular immune responses of 12 patients with culture-proved Mycobacterium marinum infection involving deep tissues were studied. Of the 12 patients, 11 failed to respond to M. marinum antigens. All of the patients had, however, normal blastogenic responses to concanavalin A, phytohemagglutinin, pokeweed mitogen, and the antigens tetanus toxoid and Candida albicans. In contrast, 9 of 14 healthy fishermen responded to the M. marinum antigens with significant in-vitro blastogenesis. Infection of deep tissues with M. marinum is associated with antigen-specific T-cell anergy to M. marinum antigens.





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