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Disseminated Multiple Antibiotic-Resistant Gonococcal Infection: Needed Changes in Antimicrobial Therapy

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▸Requests for reprints should be addressed to Larry M. Bush, M.D.; The Medical College of Pennsylvania, 3300 Henry Avenue; Philadelphia, PA 19129.

Division of Infectious Diseases, Department of Medicine, The Medical College of Pennsylvania, Philadelphia, Pennsylvania

Ann Intern Med. 1987;107(5):692-693. doi:10.7326/0003-4819-107-5-692
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This excerpt has been provided in the absence of an abstract.

Neisseria Gonorrhoeae usually causes a localized mucosal infection. However, in 1% to 3% of cases, the organism disseminates and produces various clinical syndromes (1). Two of the commoner manifestations of disseminated gonococcal infection are septic arthritis and tenosynovitis (2). In sexually active young persons, disseminated gonococcal infection is the most frequent cause of septic arthritis (2). In most studies on disseminated gonococcal infection, only strains of N. gonorrhoeae that are very sensitive to penicillin are reported to produce this syndrome (3, 4). The association between clinical virulence of the organism and dissemination may be linked to low antibiotic resistance in


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