The full content of Annals is available to subscribers

Subscribe/Learn More  >
Ideas and Opinions |

Syndromes of Acute Nonlymphocytic Leukemia

[+] Article, Author, and Disclosure Information

Grant support: in part by grants CA 26038, CA 32737, CA 33936, and CA30512 from the National Institutes of Health; The Dr. Murray Geisler Memorial Leukemia Fund; and The Louis Fagin Leukemia Research Foundation. Dr. Koeffler is a member of the Jonsson Comprehensive Cancer Center and has a Career Development Award from the National Institutes of Health.

▸Requests for reprints should be addressed to Dr. H. Phillip Koeffler: Division of Hematology/Oncology, UCLA School of Medicine, Factor Building 11-240; Los Angeles, CA 90024.

Los Angeles, California

©1987 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1987;107(5):748-758. doi:10.7326/0003-4819-107-5-748
Text Size: A A A

The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of these syndromes: acute myelomonocytic leukemia with abnormal eosinophils; acute nonlymphocytic leukemia with 11q abnormalities [biphenotypic leukemia with t(4;11); and acute monocytic leukemia with t(9;11)]; acute nonlymphocytic leukemia with t(8;21); acute promyelocytic leukemia; acute nonlymphocytic leukemia with normal or elevated platelet counts and rearranged 3q21 and 3q26; and acute nonlymphocytic leukemia with increased basophils and t(6;9). The pathogenesis of therapy-related leukemias is discussed also.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.