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Thrombotic Thrombocytopenic Purpura Associated with Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Andrea N. Leaf, MD; Linda J. Laubenstein, MD; Bruce Raphael, MD; Howard Hochster, MD; Luis Baez, MD; and Simon Karpatkin, MD
[+] Article and Author Information

Grant Support: Partial support by grant HL-13336-17 from the National Heart, Lung, and Blood Institute and by grant DAO-4314-02 from the National Institute of Drug Abuse.

Requests for Reprints: Simon Karpatkin, MD, New York University Medical Center, 550 First Avenue, New York, NY 10016.

Current Author Addresses: Drs. Leaf, Laubenstein, Raphael, Hochster, and Karpatkin: Department of Medicine and Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016. Dr. Baez: Veterans Administration Hospital, San Juan, PR 00936.


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;109(3):194-197. doi:10.7326/0003-4819-109-3-194
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The cases of 14 patients with thrombotic thrombocytopenic purpura admitted to one institution after 1980 were reviewed. Three of the fourteen cases occurred in patients with the acquired immunodeficiency syndrome (AIDS)-related complex and one occurred in a patient with probable human immunodeficiency virus (HIV) infection. The diagnosis in all four cases had been made after 1985. The association of thrombotic thrombocytopenic purpura with HIV infection was judged to be statistically significant on the basis of the proportion of patients with AIDS among the general population of patients admitted to the same institution during the same period. The fact that this association is only now being recognized suggests that there may be a long incubation period for thrombotic thrombocytopenic purpura or that the association is a rare one recognized now only because of the increased number of persons with AIDS.

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