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Autoimmune Hemolytic Anemia and Human Immunodeficiency Virus (HIV) Infection

Francesco Puppo, MD; Augusta Torresin, MD; Gaetano Lotti, MD; Enrico Balleari, MD; Giorgio Orlando, MD; and Francesco Indiveri, MD
Ann Intern Med. 1988;109(3):249-250. doi:10.7326/0003-4819-109-3-249_2
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To the editor: In patients with human immunodeficiency virus (HIV) infection, normochromic-normocytic anemia is common (1). Only four cases of autoimmune hemolytic anemia have been reported in patients with the acquired immunodeficiency syndrome (AIDS) (2), despite the frequent finding of a positive Coombs direct test in the absence of frank hemolysis (3). We describe the first case of autoimmune hemolytic anemia in a HIV-positive asymptomatic person.

In May 1987, a 38-year-old HIV-positive bisexual man had worsening asthenia, malaise, fatigue, and jaundice. The patient denied either intravenous drug abuse or recent therapeutic drug intake. On admission, he was pale and mildly


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