0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Radiation-Induced Lung Injury: A Hypersensitivity Pneumonitis?

Peter G. Gibson, MBBS; David H. Bryant, MDBS; Graeme W. Morgan, MBBS; Michael Yeates, MBBS; Viviene Fernandez, MBBS; Ronald Penny, MDBS, DSc; and Samuel N. Breit, MDBS
[+] Article and Author Information

Requests for Reprints: Samuel N. Breit, MDBS, Centre for Immunology, St. Vincent's Hospital, Victoria Street, Sydney, NSW 2010, Australia.

Current Author Addresses: Dr. Gibson, Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, 50 Charlton Avenue, East Hamilton, Ontario, L8N 4A6.

Dr. Bryant: Department of Thoracic Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Dr. Morgan: Department of Radiation Oncology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Drs. Yeates and Fernandez: Department of Nuclear Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Drs. Penny and Breit: Centre for Immunology, St. Vincent's Hospital; and University of New South Wales, Sydney, NSW 2010, Australia.


©1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;109(4):288-291. doi:10.7326/0003-4819-109-4-288
Text Size: A A A

Radiation pneumonitis occurs 6 to 12 weeks after thoracic irradiation, and is thought to be due to direct radiation-induced lung injury. Four patients who developed pneumonitis after unilateral thoracic irradiation for carcinoma of the breast were studied with bronchoalveolar lavage, gallium scan of the lung, and respiratory function tests. On the irradiated side of the chest, all four patients showed an increase in total cells recovered from the lavage fluid and a marked increase in the percentage of lymphocytes. When results for the unirradiated lung were compared with results for the irradiated lung, there was a comparable increase in total cells and percentage of lymphocytes. Gallium scans showed increases for both irradiated and unirradiated lungs. Prompt improvement was seen after corticosteroid therapy in all patients. The fact that abnormal findings occur equally in irradiated and unirradiated lung is inconsistent with simple direct radiation-induced injury and suggests an immunologically mediated mechanism such as a hypersensitivity pneumonitis.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)