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A Novel Antinuclear Antibody Associated with a Lupus-like Paraneoplastic Syndrome

Bruce Freundlich, MD; Dave Makover, MD; and Gerd G. Maul, PhD
[+] Article and Author Information

Grant Support: Partial support by grants AMO1174-03 and AR38907 from the National Institutes of Health and a grant from the Lupus Foundation of Philadelphia.

Requests for Reprints: Bruce Freundlich, MD, Rheumatology Section, 570 Maloney Building, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104.

Current Author Addresses: Drs. Freundlich and Makover: Rheumatology Section, 570 Maloney Building, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104. Dr. Maul: Wistar Institute, 36th and Spruce Streets, Philadelphia, PA 19104.


©1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;109(4):295-297. doi:10.7326/0003-4819-109-4-295
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The association of malignancy with lupus-like syndromes is rare, and the relation between these two processes is uncertain. A 71-year-old woman who presented with serositis, Raynaud phenomenon, and positive results on an antinuclear antibody test was initially thought to have systemic lupus erythematosus but was found to have ovarian adenocarcinoma. A unique sparsely speckled antinuclear antibody pattern was seen. The patient's sera reacted to novel antigens with six bands of 100, 80-78, 48, and 17 kD on Western blots not typical of reactivity for sera from patients with systemic lupus erythematosus.

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