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Rhabdomyolysis Related to Cocaine Abuse

Barry C. Herzlich, MD; Edward L. Arsura, MD; Murali Pagala, PhD; and David Grob, MD
[+] Article, Author, and Disclosure Information

Grant Support: Partial support from the Maimonides Research and Development Foundation.

Requests for Reprints: Barry C. Herzlich, MD, Department of Medicine, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, NY 11219.

Current Author Addresses: Drs. Herzlich, Arsura, and Grob: Department of Medicine, Maimonides Medical Center, Brooklyn, NY 11219; and the SUNY Health Science Center, Brooklyn, NY 11219. Dr. Pagala: Department of Medicine, Maimonides Medical Center, Brooklyn, NY 11219.

Ann Intern Med. 1988;109(4):335-336. doi:10.7326/0003-4819-109-4-335
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This excerpt has been provided in the absence of an abstract.

The rapid escalation in cocaine consumption in recent years has led to the recognition of new toxicities (1). Muscle necrosis caused by cocaine alone or with other factors has rarely been appreciated. We describe the cases of three patients with rhabdomyolysis resulting in acute renal failure in which cocaine was felt to play a major role, and discuss the manifestations and possible pathogenesis of this disorder.

Patient 1: A 27-year-old man was hospitalized with bilateral flank pain. The patient had smoked cocaine alkaloid (crack) every 3 to 4 hours for 4 consecutive days. On day 5, he became delirious and


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