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Therapy of Cushing Disease: A Consensus for Pituitary Microsurgery

James C. Melby, MD
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University Hospital, Boston University Medical CenterBoston, MA 02118


Ann Intern Med. 1988;109(6):445-446. doi:10.7326/0003-4819-109-6-445
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Transsphenoidal pituitary adenomectomy has emerged as the primary treatment of choice for Cushing disease. The overall cure rate of histologically proved pituitary tumors approaches 90% in the hands of skilled neurosurgeons as has been shown in the major series of 221 patients described by Mampalam and colleagues (1) in this issue. The remarkable success of this procedure has also been observed in 91% of 228 patients studied at the Mayo Clinic over the past 11 years (2; Laws EJ. Personal communication). When no pituitary adenoma can be found histologically the cure rate falls to slightly less than 60%. Extrasellar extension

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