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Mediastinal Germ Cell Tumor Associated with the Hemophagocytic Syndrome

Thomas J. Myers, MD; Noubar Kessimian, MD; and Stanley Schwartz, MD
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Requests for Reprints: Thomas J. Myers, MD, 109 Beechwood Avenue, Pawtucket, RI 02860.

Current Author Addresses: Dr. Myers: 109 Beechwood Avenue, Pawtucket, RI 02860.

Drs. Kessimian and Schwartz: Department of Pathology, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860.

Ann Intern Med. 1988;109(6):504-505. doi:10.7326/0003-4819-109-6-504
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This excerpt has been provided in the absence of an abstract.

The hemophagocytic syndrome is a reactive disorder of the monocyte-macrophage system characterized clinically by an acute onset, fever, lymphadenopathy, hepatosplenomegaly, and pancytopenia (1). The hemophagocytic syndrome can be differentiated from malignant histiocytosis by a potentially self-limited clinical course and by histologic findings of generalized monocyte-macrophage proliferation with prominent hemophagocytosis but without features of malignancy (1, 2). The hemophagocytic syndrome has been reported in association with infections ( 1 ), non-Hodgkin lymphoma (2), Hodgkin disease (3), chronic lymphocytic leukemia (4), acute lymphocytic (5) and nonlymphocytic (6) leukemias, and gastric carcinoma (7).

Extragonadal germ cell tumors are found in 10% to 15%


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