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Maintenance Amphotericin B for Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS)

Abigail Zuger, MD; Michael Schuster, MD; Michael S. Simberkoff, MD; James J. Rahal, MD; and Robert S. Holzman, MD
[+] Article and Author Information

This paper was presented in part at the Second International Conference on AIDS held 23 to 25 June 1986 in Paris, France.

Requests for Reprints: Robert S. Holzman, MD, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016.

Current Author Addresses: Drs. Zuger and Holzman: Department of Medicine, New York University School of Medicine. New York, NY 10016.

Dr. Simberkoff: New York Veterans Administration Medical Center, New York, NY 10010.

Dr. Schuster: Department of Medicine, Goldwater Memorial Hospital, New York, NY 10044.

Dr. Rahal: Booth Memorial Medical Center, Flushing, NY 11355.


Ann Intern Med. 1988;109(7):592-593. doi:10.7326/0003-4819-109-7-592
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We previously reported our experience (1) with the treatment of cryptococcal infections in patients with the acquired immunodeficiency syndrome (AIDS). Like other investigators (2, 3) we noted a high relapse rate and a poor response to treatment among patients with relapsed infections. Continued weekly infusions of amphotericin B after a standard course of therapy seemed to offer our patients some protection against relapse. Of seven patients who received maintenance therapy with amphotericin B, none had relapses; four of eight patients had relapses when maintenance therapy was not administered. This observation prompted us to recommend maintenance amphotericin B for all patients

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