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Pulmonary Hemorrhage with Diffuse Alveolar Infiltrates in Men with High-Volume Choriocarcinoma

Joshua O. Benditt, MD; Harrison W. Farber, MD; Jonathan Wright, MD; and Anand B. Karnad, MD
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Requests for Reprints: Joshua O. Benditt, MD, Pulmonary Center, Boston University School of Medicine, 80 East Concord Street, K-603, Boston, MA 02118.

Current Author Addresses: Drs. Benditt and Farber: Pulmonary Center, Boston University School of Medicine, Boston, MA 02118.

Drs. Wright and Karnad: Division of Hematology-Oncology, Boston City Hospital, Boston, MA 02118.

Ann Intern Med. 1988;109(8):674-675. doi:10.7326/0003-4819-109-8-674
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This excerpt has been provided in the absence of an abstract.

Choriocarcinoma in men, a rare tumor comprising less than 5% of germ cell tumors, is frequently associated with an elevated serum beta-human chorionic gonadotropin (B-HCG) level. Despite high cure rates reported in men with advanced germ cell tumors of the testis, patients with choriocarcinoma and markedly elevated B-HCG levels (> 50 000 mIU/mL) continue to have a poor prognosis (1-3). Choriocarcinoma is a hemorrhagic tumor, and complications from bleeding at the primary or metastatic site may contribute significantly to the poor prognosis (1, 4).

Hemorrhagic complications in women with choriocarcinoma have been well described (5-7); however, similar complications in men


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