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Partner Drugs: A New Outlook for Bacterial Meningitis

Elaine Tuomanen, MD, CM
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Grant Support: In part by grant #AI23459 from the National Institutes of Health and a Career Investigator Award from the I.T. Hirschl Trust.

Requests for Reprints: Elaine Tuomanen, MD, CM, The Rockefeller University, 1230 York Avenue, New York, NY 10021.

The Rockefeller University, New York, New York

Ann Intern Med. 1988;109(9):690-692. doi:10.7326/0003-4819-109-9-690
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This excerpt has been provided in the absence of an abstract.

Surprisingly, the morbidity and mortality rates from bacterial meningitis have remained stable since the advent of antibiotics in the 1930s. A persistent mortality rate of 30% for pneumococcal meningitis (1) is not acceptable in the current chemotherapeutic era, yet the development of more highly bactericidal antibiotics has not improved disease outcome. Recently, important clues have emerged to explain this paradox. The new concept propelling changes in therapeutic regimens is that reducing inflammation is required in addition to killing bacteria in order to minimize neurologic injury during infections in the subarachnoid space. Within the next 5 years introduction of ancillary modes


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