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Metronidazole-Associated Pancreatitis

Kurt A. Sanford, MD; James E. Mayle, MD; Howard A. Dean, DO; and David S. Greenbaum, MD
[+] Article and Author Information

Requests for Reprints: Kurt A. Sanford, MD, Department of Medicine, Division of Gastroenterology, B-338 Clinical Center, Michigan State University, East Lansing, MI 48824.

Current Author Addresses: Drs. Sanford, Mayle, and Greenbaum: Department of Medicine, B-338 Clinical Center, Michigan State University, East Lansing, MI 48824.

Dr. Dean: Department of Medicine, B311D West Fee Hall, Michigan State University, East Lansing, MI 48824.


Ann Intern Med. 1988;109(9):756-757. doi:10.7326/0003-4819-109-9-756
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Metronidazole is a widely used antiprotozoal drug prescribed for infections with Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and Gardnerella vaginalis as well as for generalized anaerobic infections. We report a case of recurrent pancreatitis associated with metronidazole-treated Gardnerella vaginalis infections.

A previously healthy, obese, 23-year-old black woman was hospitalized after 4 days of epigastric, right upper quandrant, and back pain, associated with anorexia, nausea, and low-grade fever. The patient had previously been treated twice for gonorrhea salpingitis and three times for pneumonia. She denied a personal or family history of pancreatitis, gallbladder disease, liver disease, or hyperlipidemias. She reported only

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