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Glucagonoma Syndrome and Bronchial Carcinoma

Werner Hunstein, MD; Lorenz H. Trümper, MD; Reinhard Dummer, MD; and Karl Schwechheimer, MD
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Requests for Reprints: Werner Hunstein, MD, Medizinische Klinik and Poliklinik V, Hospitalstrasse 3, 6900 Heidelberg, West Germany.

Current Author Addresses: Drs. Hunstein, Trümper, and Dummer: Medizinische Klinik und Poliklinik V, Hospitalstrasse 3, 6900 Heidelberg, West Germany. Dr. Schwechheimer: Institut für Pathologie, Albertstrasse 19, 7800 Freiburg, West Germany.

Ann Intern Med. 1988;109(11):920-921. doi:10.7326/0003-4819-109-11-920
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This excerpt has been provided in the absence of an abstract.

Glucagonoma syndrome is a rare but well-defined clinical entity caused by the excessive production of glucagon in an alpha cell tumor of the pancreas. The principal features of this syndrome, apart from a considerably elevated glucagon serum level, include a typical skin rash (necrolytic migratory erythema), diabetes mellitus or impaired glucose tolerance, weight loss, and anemia. The first case was reported by Becker and associates in 1942 (1), but the association of ectopic glucagon production and necrolytic erythema was defined as Glucagonoma syndrome as late as 1974 by Mallinson and colleagues (2).

More than 120 cases have been described, allowing


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Glucagonoma syndrome and bronchial carcinoma. Ann Intern Med 1988;109(11):920-1.
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