0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

The Non-Hodgkin Lymphoma Pathologic Classification Project: Long-Term Follow-Up of 1153 Patients with Non-Hodgkin Lymphomas

Richard Simon, PhD; Sylvain Durrleman, MD; Richard T. Hoppe, MD; Gianni Bonadonna, MD; Clara D. Bloomfield, MD; Richard A. Rudders, MD; Bruce D. Cheson, MD; and Costan W. Berard, MD
[+] Article and Author Information

Requests for Reprints: Richard Simon, PhD, National Cancer Institute, Executive Plaza North, Room 739, Bethesda, MD 20892.

Current Author Addresses: Drs. Simon and Durrleman: Executive Plaza North, Room 739, Division of Cancer Treatment, Bethesda, MD 20892.

Dr. Hoppe: Department of Radiation Oncology, Room A091, Stanford University, Stanford, CA 94305.

Dr. Bonadonna: Istituto Nazionale Tumori, Via Venezian, 1, Milan 20133, Italy.

Dr. Bloomfield: Box 277 UMHC, University of Minnesota, Minneapolis, MN 55455.

Dr. Rudders: New England Medical Center and Tufts University School of Medicine, 171 Harrison Avenue, Boston, MA 02111.

Dr. Cheson: NCI, Executive Plaza North, Room 741, Bethesda, MD 20892.

Dr. Berard: 4576 Park Avenue, Memphis, TN 38117.


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;109(12):939-945. doi:10.7326/0003-4819-109-12-939
Text Size: A A A

Study Objective: To document the long-term prognosis of patients with non-Hodgkin lymphoma treated between 1971 and 1975 and to determine how the prognosis varies by histologic subtype and stage.

Setting: Three cancer referral centers in the United States and one center in Italy.

Patients: A consecutive sample of 1153 previously untreated patients with non-Hodgkin lymphoma. At the time of analysis, 71% of the patients had died and the median follow-up for patients still alive was 11.2 years.

Measurements and Main Results: The 10-year survival proportions were 45% (CI, 40% to 50%); 26% (CI, 22% to 30%); and 23% (CI, 18% to 30%) for patients with low-, intermediate-, and high-grade lymphomas, respectively. Patients with intermediate- and high-grade lymphomas were curable, but this was not apparent for patients with advanced stage low-grade lymphomas. For the low-grade follicular small cleaved and follicular mixed lymphomas, the Ann Arbor staging system distinguished the prognosis of patients with stage I disease from those with more extensive involvement. For the diffuse large cell and immunoblastic lymphomas, the Ann Arbor staging system distinguished long-term prognosis for patients with stage I disease from patients with stage II disease and those with more disseminated involvement.

Conclusions: The probability of long-term survival for unselected patients with non-Hodgkin lymphoma can be substantial. Long-term prognosis depends on the histologic subtype of the tumor and the extent of dissemination. The Working Formulation for non-Hodgkin lymphomas is a simple and useful nomenclature for selecting treatment and reporting results. The Ann Arbor staging system is a useful but imperfect prognostic indicator.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)