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Management of Antibiotic-Resistant Neisseria gonorrhoeae

Franklyn N. Judson, MD
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Requests for Reprints: Franklyn N. Judson, MD, Denver Public Health, 605 Bannock Street, Denver CO 80204-4507.

University of Colorado and Denver Disease
Control Service
Denver, Colorado

Ann Intern Med. 1989;110(1):5-7. doi:10.7326/0003-4819-110-1-5
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This excerpt has been provided in the absence of an abstract.

Because man is the only natural host of the species Neisseria gonorrhoeae, the ability of the gonococcus to thrive in a hostile antibiotic world serves as testimony both to the genetic principles of natural selection and to the unwillingness of its human host to limit sexual contacts to long-term mutually monogamous relationships.

From 1945 to 1954, the first decade that penicillin was used to treat gonorrhea, antimicrobial resistance and treatment failures were extremely rare. Even the smallest doses of penicillin, tetracycline, or chloramphenicol eradicated the helpless gonococcus, and a movement by ecologists of the day to place N. gonorrhoeae on


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