0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Calcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis

Susan M. Ott, MD; and Charles H. Chesnut III, MD
[+] Article and Author Information

Grant support: The study was supported by Hoffmann-La Roche Inc. Dr. Ott is the recipient of a National Institutes of Health (NIH) Clinical Investigator Award #AR-01244. The study used the General Clinical Research Center, funded by NIH grant #RR-00037.

Requests for Reprints: Susan M. Ott, MD, Nuclear Medicine, RC-70, University of Washington, Seattle, WA 98195.

Current Author Addresses: Drs. Ott and Chesnut: Nuclear Medicine, RC-70, University of Washington, Seattle, WA 98195.


Ann Intern Med. 1989;110(4):267-274. doi:10.7326/0003-4819-110-4-267
Text Size: A A A

Study Objective: To determine if calcitriol is an effective treatment in postmenopausal osteoporosis.

Design: Double-blind, randomized clinical trial of 2 years' duration.

Setting: University medical center with patients recruited by media announcements.

Patients: Eighty-six postmenopausal women with vertebral compression fractures.

Interventions: Patients were treated with calcitriol or placebo. Mean dose was 0.43 µg/d. Dietary calcium was 1000 mg/d (24.9 mmol/d). The medication dose and dietary calcium were adjusted for hypercalciuria or hypercalcemia.

Measurements and Main Results: No significant differences between placebo and control groups were seen in the percent change in total body calcium (0.4% ± 1.0 compared with 0.0% ± 0.9), single photon absorptiometry (-0.5% ± 1.2 compared with -3.1% ± 0.9) or dual photon absorptiometry (0.0% ± 1.7 compared with -1.0% ± 2.2). New fractures were seen in 16% of the placebo group and 26% of the calcitriol group, so the difference in percent fractures was 10% (95% CI, -5.7% to 25.7%). Bone biopsies did not show changes in either group. The calcitriol group had significantly higher serum and urine calcium values, but renal function was not worse than in the placebo group.

Conclusions: Calcitriol is not an effective treatment for established postmenopausal osteoporosis.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)