The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

A Vasculopathy with Deposition of Lambda Light Chain Crystals

Giancarlo C. Stone, MD; Bruce A. Wall, MD; Ina R. Oppliger, MD; Mark H. Wener, MD; Susan L. Jolly, MD; Augusto Aguirre, MD; Regina Dwyer, MD; and Peter A. Simkin, MD
[+] Article, Author, and Disclosure Information

Grant Support: Supported in part by grants T32 AR-07108 and R01 AR-32811 from the National Institute of Arthritis, Musculoskeletal and Skin Diseases and by the Townsend-Henderson Fund.

Requests for Reprints: Peter A. Simkin, MD, Division of Rheumatology, RG-28, Department of Medicine, University of Washington, Seattle, WA 98195.

Current Author Addresses: Dr. Stone: Department of Medicine, ZB-30, Pacific Medical Center, University of Washington, Seattle, WA 98195. Dr. Wall: 1211 Dublin Road, Columbus, OH 43215. Drs. Oppliger, Wener, and Simkin: Division of Rheumatology, RG-28, Department of Medicine, University of Washington, Seattle, WA 98195. Dr. Jolly: 4936 Kristie Falls, Hilliard, OH 43026.

Dr. Aguirre: Riverside Hospital, 3535 Olentangy River Road, Columbus, OH 43214.

Dr. Dwyer: Department of Medicine, RG-20, University of Washington, Seattle, WA 98195.

© 1989 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1989;110(4):275-278. doi:10.7326/0003-4819-110-4-275
Text Size: A A A

An 82-year-old man and a 34-year-old woman developed subacute, obstructive, fatal vasculopathies characterized by extensive crystalline tissue deposits and monoclonal lambda light chain serum components. Cryocrystalglobulinemia was also present in one patient, and the purified crystals contained only lambda light chain dimers. Although the presentation of these patients resembled that of systemic necrotizing vasculitis, histologic evidence of inflammation was lacking and their subsequent rapid clinical deterioration was not altered by corticosteroid therapy, and in one case cyclophosphamide and plasmapheresis. Both patients died within 3 weeks of presentation.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.