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Interferon Therapy for Kaposi Sarcoma Associated with the Acquired Immunodeficiency Syndrome (AIDS)

Jerome E. Groopman, MD; and David T. Scadden, MD
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Requests for Reprints: Jerome E. Groopman, MD, New England Deaconess Hospital/Harvard Medical School, 110 Francis Street, Suite 4A, Boston, MA 02215.

New England Deaconess Hospital and
Harvard Medical School
Boston, Massachusetts

Ann Intern Med. 1989;110(5):335-337. doi:10.7326/0003-4819-110-5-335
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This excerpt has been provided in the absence of an abstract.

The observation that recombinant interferon-alpha is an active antineoplastic agent in Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS) grew out of the initial studies of this agent by Krown and colleagues nearly 5 years ago ( 1 ). A clear role for interferon-alpha in therapy for this neoplasm is now emerging.

Kaposi sarcoma is the commonest neoplastic complication of AIDS, occurring in approximately 40% of patients. The marked disparity in the incidence of Kaposi sarcoma in homosexual (approximately 40%) when compared with the incidence in heterosexual (approximately 10%) patients suggests a cause of the sarcoma that is more


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