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Acute Pancreatitis Due to 5-Aminosalicylate

Bashir Sachedina, MD; Fred Saibil, MD; Lawrence B. Cohen, MD; and Janet Whittey, BSCPhm
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Requests for Reprints: Fred Saibil, MD, Sunnybrook Medical Centre, 2075 Bayview Avenue, Suite H-G962, Toronto, Ontario, Canada M4N 3M5.

Current Author Addresses: Dr. Sachedina: Toronto Western Hospital, Division of Gastroenterology, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8.

Drs. Saibil and Cohen, and Ms. Whittey: Sunnybrook Medical Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

Ann Intern Med. 1989;110(6):490-492. doi:10.7326/0003-4819-110-6-490
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This excerpt has been provided in the absence of an abstract.

Acute pancreatitis has been described as a complication of sulfasalazine therapy in patients with inflammatory bowel disease (1-3). In a critical review, Mallory and Kern (4) suggested that the sulfonamide component of sulfasalazine was responsible for this adverse effect because of the structural similarity of the sulfonamides to the thiazide diuretics, which are a well recognized cause of drug-induced pancreatitis. Sulfasalazine comprises sulfapyridine linked by an azo bond to 5-aminosalicylate (5-ASA), which is the active ingredient.

We report a case of 5-aminosalicylate-induced pancreatitis (Asacol, Norwich Eaton Pharmaceuticals Inc., Cambridge, Ontario, Canada). This complication has not previously been published with the


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