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The Pseudo-Sézary Syndrome with CD8 Phenotype in a Patient with the Acquired Immunodeficiency Syndrome (AIDS)

Michel Janier, MD; Christine Katlama, MD; Béatrice Flageul, MD; Françoise Valensi, MD; Isabelle Moulonguet, MD; François Sigaux, MD; Denise Dompmartin, MD; and Jean Civatte, MD
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Requests for Reprints: Michel Janier, MD, Department of Dermatology, Hôpital Saint-Louis, 40 Rue Bichat, 75010 Paris, France.

Current Author Addresses: Drs. Janier, Flageul, Valensi, Moulonguet, Sigaux and Civatte: Hôpital Saint-Louis, 75010 Paris, France.

Drs. Katlama and Dompmartin: Hôpital Claude Bernard, 75019 Paris, France.


Ann Intern Med. 1989;110(9):738-740. doi:10.7326/0003-4819-110-9-738
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Hodgkin disease (1) and extranodal high-grade non-Hodgkin lymphomas of the B or non-T phenotype (2) have been reported in patients infected with the human immunodeficiency virus type 1 (HIV-1), but

Figure 1. Skin biopsy sample shows dense lymphoid infiltrate made of Sezary-like cells and large atypical lymphocytes (hematoxylin and eosin; original magnification, X 400); skin biopsy sample with peroxidase anti-CD8 staining (left); numerous cells with CD8 phenotype in the dermis and mild epidermotropism (middle); and large atypical circulating lymphocytes (right).

T-cell lymphomas are exceptional. We report the case of a patient with the acquired immunodeficiency syndrome (AIDS) who developed erythroderma mimicking the Sézary syndrome.

Case Report: A 25-year-old white homosexual man with a 2-year history of known HIV-1 seropositivity developed a photo-distributed, pruritic, erythematous, and papular lichenoid eruption on the face and dorsal aspect of the hands and forearms in July 1986, a few weeks after the administration of suramin,

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