The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Antiarrhythmic Agents and the Danger of Proarrhythmic Events

Mark E. Josephson, MD
[+] Article, Author, and Disclosure Information

Grant Support: Supported in part by grant HL07346 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland; and grants from The American Heart Association, Southeastern Pennsylvania Chapter, Philadelphia, Pennsylvania.

Requests for Reprints: Mark E. Josephson, MD, Cardiovascular Section, 994 Founders Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

Ann Intern Med. 1989;111(2):101-103. doi:10.7326/0003-4819-111-2-101
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Only in the last decade have the proarrhythmic effects of antiarrhythmic agents been evaluated. Most recent studies (1-3) have focused on drugs used to treat ventricular arrhythmias. These studies have dealt with patients primarily being treated for ventricular arrhythmias. The ventricular proarrhythmic effect of these agents has not been evaluated carefully when used to manage supraventricular arrhythmias despite the fact that the induction of polymorphic ventricular tachycardia by antiarrhythmic agents was initially documented in patients being treated for atrial fibrillation (4). Thus, whereas much of the attention to ventricular proarrhythmias has been on treatment of ventricular arrhythmias, similar attention must


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.