0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Visceral Leishmaniasis in Patients Infected with Human Immunodeficiency Virus (HIV)

Juan Berenguer, MD; Santiago Moreno, MD; Emilia Cercenado, PhD; Juan C.L. Bernaldo de Quiros, MD; Antonio Garcia de la Fuente, MD; and Emilio Bouza, MD
[+] Article and Author Information

Requests for Reprints: Emilio Bouza, MD, Servicio de Microbiología Clínica, Hospital General Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain.

Current Author Addresses: Drs. Berenguer, Moreno, Cercenado, Bernaldo de Quirós, and Bouza: Servicio de Microbiologia Clinica, Hospital General Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain.

Dr. García de la Fuente: Servicio de Medicina Interna, Hospital General Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain.


© 1989 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1989;111(2):129-132. doi:10.7326/0003-4819-111-2-129
Text Size: A A A

In an 8-month period nine patients with human immunodeficiency virus (HIV) infection were diagnosed as having visceral leishmaniasis; all diagnoses were based on cultures (eight from bone marrow and one from the skin). Visceral leishmaniasis developed before full-blown acquired immunodeficiency syndrome (AIDS) in seven patients and at the same time as or after AIDS in the other two patients. Three patients had a history of leishmaniasis. Clinical manifestations and laboratory findings were atypical. Leishmania species were cultured from samples taken from all patients; however, six patients had an insignificant antileishmanial antibody titer and Leishmania amastigotes were not seen in their bone marrow smears. Four isolates were identified by isoenzyme analysis as Leishmania donovani infantum. Five patients died, including two patients who had completed at least one 3-week course of therapy with N-methylglucamine antimoniate. Screening should be done for visceral leishmaniasis in patients with HIV infection who live or travel in areas where the disease is endemic. The diagnosis of visceral leishmaniasis may frequently be missed if cultures are not done.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)