0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Fulminant Hepatic Failure after Ingestion of Sustained-Release Nicotinic Acid

Gerard E. Mullin, MD; Joel K. Greenson, MD; and Mack C. Mitchell, MD
[+] Article and Author Information

Requests for Reprints: Mack C. Mitchell, Jr, MD, Division of Gastroenterology, The Johns Hopkins School of Medicine, Hunterian 409, 725 North Wolfe Street, Baltimore, MD 21205.

Current Author Addresses: Drs. Mullin and Mitchell: Division of Gastroenterology, The Johns Hopkins School of Medicine, Hunterian 409, 725 North Wolfe Street, Baltimore, MD 21205.

Dr. Greenson: Department of Pathology, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205.


Ann Intern Med. 1989;111(3):253-255. doi:10.7326/0003-4819-111-3-253
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Nicotinic acid is an effective, widely used treatment for hypercholesterolemia (1). Hepatotoxicity is a rare complication of therapy, which usually occurs with ingestion of more than 3 g daily. In most cases, patients have jaundice, pruritus, and mild elevations in serum bilirubin, alkaline phosphatase, and aminotransferase levels, although, in some instances, more severe hepatocellular injury has occurred (2). We report the case of a patient who developed fulminant hepatic failure shortly after switching to sustained-release nicotinic acid after having taken ordinary nicotinic acid for over 1 year without side effects.

Case Report: In February 1987, after having coronary angioplasty, a

...

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)