The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Alpha-Interferon for Severe Cold Agglutinin Disease

Brian M. O'Connor, MD; Jacqueline S. Clifford, BS; William D. Lawrence, MD; and Gerald L. Logue, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: William D. Lawrence, MD, Century Medical Associates, 1616 Kensington Avenue, Buffalo, NY 14215.

Current Author Addresses: Drs. O'Connor and Logue: Department of Medicine, Buffalo Veterans Administration Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215.

Ms. Clifford: Department of Pathology, Buffalo Veterans Administration Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215.

Dr. Lawrence: Century Medical Associates, 1616 Kensington Avenue, Buffalo, NY 14215.

Ann Intern Med. 1989;111(3):255-256. doi:10.7326/0003-4819-111-3-255
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Cold agglutinin disease may be classified as primary or secondary. Monoclonal IgM (occasionally IgG or IgA) proteins with the ability to bind to erythrocytes below body core temperature are found in the sera of patients with the primary (idiopathic) and secondary forms associated with lymphoproliferative disorders (1). In these disorders mild to moderate hemolytic anemia results from the deposition of complement as the cold agglutinin binds to the erythrocyte in the acral circulation. On exposure to cold, episodes of hemoglobinuria related to marked intravascular hemolysis may occur. Exposure to cold may also produce painful acrocyanosis caused by sludging and deoxygenation


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.