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Co-infection with Human Immunodeficiency Virus-Type 1 (HIV-1) and Cytomegalovirus in Two Intravenous Drug Users

Antonio Bonetti, MD; Rainer Weber, MD; Markus W. Vogt, MD; Werner Wunderli, PhD; Walter Siegenthaler, MD; and Ruedi Lüthy, MD
[+] Article and Author Information

Grant Support: Supported in part by grant 3.584-7 from the Swiss National Science Foundation, the EMDO Foundation, and a grant from the Swiss Federal Office of Public Health.

Requests for Reprints: Ruedi Lüthy, MD, Division of Infectious Diseases, University Hospital, CH-8091 Zürich, Switzerland.

Current Author Addresses: Drs. Bonetti, Weber, Vogt, Lüthy: Division of Infectious Diseases, University Hospital, CH-8091 Zürich, Switzerland.

Dr. Wunderli: Institute for Immunology and Virology, University of Zürich, CH-8091 Zürich, Switzerland.

Dr. Siegenthaler: Professor and Chairman, Department of Medicine, University Hospital, CH-8091 Zürich, Switzerland.


©1989 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1989;111(4):293-296. doi:10.7326/0003-4819-111-4-293
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A mononucleosis-like illness is frequently recognized retrospectively as the first manifestation of infection with human immunodeficiency virus-type 1 (HIV-1). This acute but transient retroviral syndrome may include symptoms such as malaise, fever, sweats, myalgia, arthralgia, maculopapular rash, diarrhea, and lymphocytic meningitis. We observed two intravenous drug users who developed a severe, febrile illness with subsequent oral thrush (one also had biopsy-proven esophageal candidiasis). Both patients had weight loss, arthralgia, myalgia, and fatigue. These symptoms occurred two weeks after needle-sharing and persisted for 7 weeks in one patient and 10 weeks in the other. Both patients had serologic evidence for both acute HIV-1 and cytomegalovirus infection. Cytomegalovirus enhances HIV-1 replication in vitro, presumably by stimulating HIV-1 gene expression. Thus, the observed syndrome suggests that this viral interaction may be clinically significant because it appears to cause severe additional morbidity, which is not typical for primary infection with HIV-1. After 6 months of follow-up, one patient is completely asymptomatic but shows markedly reduced CD4+ lymphocytes. The other patient developed persistent lymphadenopathy after the acute illness, but is feeling well 21 months after infection.

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