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Effective Reduction in the Serum 1,25-Dihydroxyvitamin D and Calcium Concentration in Sarcoidosis-Associated Hypercalcemia with Short-Course Chloroquine Therapy

John S. Adams, MD; Marie M. Diz, BS; and Om P. Sharma, MD
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Grant Support: Supported in part by grants DK33139 and M01-RR-43 from the National Institutes of Health.

Requests for Reprints: John S. Adams, Cedars-Sinai Medical Center, Endocrinology Department, 8700 Beverly Boulevard, Los Angeles, CA 90048.

Current Author Addresses: Dr. Adams and Ms. Diz: Cedars-Sinai Medical Center, Endocrinology Department, 8700 Beverly Boulevard, Los Angeles, CA 90048.

Dr. Sharma: LAC/USC Medical Center, GHN 11-900, 1200 North State Street, Los Angeles, CA 90033.

Ann Intern Med. 1989;111(5):437-438. doi:10.7326/0003-4819-111-5-437
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The chronic administration of drugs of the 4-amino quinoline class, including quinacrine, chloroquine, and hydroxychloroquine, has been used for many years to effectively manage many of the cutaneous (1) and extracutaneous symptoms (2) of sarcoidosis. More recently chloroquine (3) and hydroxychloroquine (4) were shown to reduce the extrarenal synthesis of 1,25-dihydroxyvitamin D (l,25-(OH)2-D) and to lower the serum calcium concentration and fractional urinary calcium excretion rate in hypercalcemic-hypercalciuric patients with sarcoidosis. These reports (3, 4) claim that the 1,25-(OH)2-D and calcium lowering effect of these drugs requires weeks, if not months, of therapy. However, measurements of the serum


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