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Early Treatment for Acute Ischemic Stroke

William G. Barsan, MD; Thomas G. Brott, MD; Charles P. Olinger, MD; and John R. Marler, MD
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Requests for Reprints: William G. Barsan, MD, Department of Emergency Medicine, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45267-0769.

University of Cincinnati
Cincinnati, OhioNational Institute for Neurological Disorders and Stroke
Bethesda, Maryland

Ann Intern Med. 1989;111(6):449-451. doi:10.7326/0003-4819-111-6-449
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Early treatment for ischemic stroke has been a difficult objective to attain and has been stated to be impractical for several reasons. Stroke patients, who usually have no pain and may not be aware of their deficits, may not seek immediate medical care. In addition, it is impossible to detect all patients with reversible ischemic deficits unless at least 24 hours have passed. Finally, there is no proven treatment to reverse ischemic stroke, whether initiated early or late. For these reasons, early treatment has not been emphasized in studies of acute ischemic stroke in humans.

In a collective review (1)


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