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Angiotensin Converting Enzyme Inhibitors: The End of End-Stage Renal Disease?

Peter U. Feig, MD; and Gale H. Rutan, MD, MPH
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Requests for Reprints: Peter U. Feig, MD, 448 Scaife Hall, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.

University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Ann Intern Med. 1989;111(6):451-453. doi:10.7326/0003-4819-111-6-451
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More than 30 000 persons annually develop end-stage renal disease as a result of inexorably progressive renal insufficiency. Because of successful development and funding of maintenance therapy, over 120 000 patients live either on chronic dialysis or with renal allografts. The program has high morbidity and costs about $3 billion per year, that is, approximately $25 000 per patient. Further successes in prolonging life on maintenance therapy without affecting the rate of development of renal failure will result in further increases in this number, with the fastest growth among persons over age 65 (1). Arresting the progression of renal deterioration


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