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Hepatic Toxicity after Acebutolol Therapy

L. Ann Tanner, BS, RPh; L.A. Bosco, MD, MPH; and Hyman J. Zimmerman, MD
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Requests for Reprints: L. A. Bosco, MD, MPH, Room 15-42, HFD-733, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857.

Current Author Addresses: Ms. Tanner and Dr. Bosco: Division of Epidemiology and Surveillance, Office of Epidemiology and Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857.

Dr. Zimmerman: Hepatic Pathology Department, Armed Forces Institute of Pathology, Washington, DC 20306-6080.

Ann Intern Med. 1989;111(6):533-534. doi:10.7326/0003-4819-111-6-533
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This excerpt has been provided in the absence of an abstract.

Elevated serum transaminase and alkaline phosphatase levels have occurred in association with most of the beta-adrenoreceptor blocking agents (1). These reactions, however, have not been reported in the literature. Although two groups from West Germany (2-4) reported pathologic findings consistent with hepatitis in association with propranolol, these cases were confounded by other compounds associated with hepatic injury. Liver toxicity has not been previously reported with acebutolol (Sectral; Wyeth-Ayerst Laboratories, Philadelphia, Pennsylvania), a cardioselective adrenoreceptor blocking agent with intrinsic sympathomimetic activity. We report a possible association between exposure to acebutolol and liver toxicity.

Case Reports: Since 1985 the Division of Epidemiology


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