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Antithrombin III Concentrate for Treatment of Chronic Leg Ulcers in Sickle Cell-Beta Thalassemia: A Pilot Study

Elio Cacciola, MD; Rosario Giustolisi, MD; Roberto Musso, MD; Angela Longo, BD; and Emma Cacciola, MD
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Grant Support: Supported in part by a grant from Ministero Publica Istruzione, Rome, Italy.

Requests for Reprints: Elio Cacciola, MD, Chair of Hematology, University of Catania, Ospedale Ferrarotto, Via S. Citelli, 6, 95124 Catania, Italy.

Current Author Addresses: Drs. Cacciola, Giustolisi, Musso, Longo, and Cacciola: Chair of Hematology, University of Catania, Ospedale Ferrarotto, Via S. Citelli, 6, 95124 Catania, Italy.

Ann Intern Med. 1989;111(6):534-536. doi:10.7326/0003-4819-111-6-534
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This excerpt has been provided in the absence of an abstract.

Chronic leg ulcers are a common distressing complication in patients with sickle cell-beta thalassemia and are difficult to heal. The pathogenic mechanism of this complication is not known although some factors have been implicated, such as severe anemia or zinc deficiency (1, 2). In this context, however, it is significant that persons with either beta-thalassemia or sickle-cell anemia are regarded as being at thrombotic risk (3, 4).

In sickle-cell disease, the recurrent vasocclusive episodes occurring in several areas of the body have been reported to be related to the sickling, which in turn can trigger the activation of blood coagulation


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