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Phencyclidine Pharmacokinetics after a Massive Overdose

J. Edward Jackson, MD
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Requests for Reprints: J. Edward Jackson, MD, Department of Medicine, H-111-E, University of California, San Diego, 225 Dickinson Street, San Diego, CA 92103.

Current Author Address: Dr. Jackson: Department of Medicine, H-111-E University of California, San Diego, 225 Dickinson Street, San Diego, CA 92103.

Ann Intern Med. 1989;111(7):613-615. doi:10.7326/0003-4819-111-7-613
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Phencyclidine abuse remains a major problem particularly in urban centers. Regarding the management of phenycyclidine intoxication, recommendations have been made to hasten elimination of phencyclidine by urine acidification (1-3). However, more recent pharmacokinetic studies suggest that phencyclidine is cleared primarily by metabolism and has a large volume of distribution (6.2 L/kg) (4, 5). The pharmacokinetics of phenyclidine after massive overdosage have not been characterized. This report details the time course of plasma phencyclidine concentrations in a patient who had severe symptoms after massive overdosage. These phencyclidine levels represent the highest ever reported for a survivor of phencyclidine intoxication.

Case Report:


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