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Fluoride Therapy for the Vertebral Crush Fracture Syndrome: A Status Report

Robert P. Heaney, MD; David J. Baylink, MD; C. Conrad Johnston Jr., MD; L. Joseph Melton III, MD; Pierre J. Meunier, MD; Timothy M. Murray, MD; and Charles Nagant de Deuxchaisnes, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Robert P. Heaney, MD, Creighton University, California at 24th Street, Omaha, NE 68178.

Current Author Addresses: Dr. Heaney: Creighton University, California at 24th Street, Omaha, NE 68178.

Dr. Baylink: Jerry L. Pettis Memorial Veterans Hospital, 11201 Benton Street, Loma Linda, CA 92357.

Dr. Johnston: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46223.

Dr. Melton: Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905.

Dr. Meunier: Hopital Edouard-Herriot, place d' Arsonval, 69374 Lyon, Cedex 2, France.

Dr. Murray: St. Michael's Hospital, 38 Shuter Street, Room 233, Toronto, Ontario, Canada M5B 1A6.

Dr. Nagant de Deuxchaisnes: Arthritis Unit, Louvain University, St.-Luc University Hospital, Avenue Hippocrate, Brussels-B1200, Belgium.

Ann Intern Med. 1989;111(8):678-680. doi:10.7326/0003-4819-111-8-678
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Fluoride has been proposed as a therapy for the vertebral crush fracture syndrome for many years; such proposals have been based largely on the well-characterized syndrome of fluoride intoxication (fluorosis), which is marked by increased skeletal mass and sometimes exuberant bony overgrowths (1-4). For various reasons, including the inability to develop a patentable product, the clinical studies necessary to follow this lead and establish efficacy and safety have proceeded slowly. Nevertheless, much information on fluoride use in the treatment of the vertebral crush fracture syndrome has been amassed, and during the past 9 years fluoride therapy has been approved for


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