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Digital Necrosis and Disseminated Pneumocystis carinii Infection after Aerosolized Pentamidine Prophylaxis

Richard T. Davey Jr, MD; David Margolis, MD; David Kleiner, MD; Lawrence Deyton, MD; and William Travis, MD
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Requests for Reprints: Richard T. Davey Jr, MD, Laboratory of Immunoregulation, NIAID/NIH, Building 10, Room 11B13, Bethesda, MD 20892.

Current Author Addresses: Drs. Davey, Margolis, and Deyton: National Institute of Allergy and Infectious Diseases, Building 10, Room 11B13, National Institutes of Health, Bethesda, MD 20892.

Drs. Kleiner and Travis: Laboratory of Pathology, National Cancer Institute, Building 10, Room 2N212, National Institutes of Health, Bethesda, MD 20892.

Ann Intern Med. 1989;111(8):681-682. doi:10.7326/0003-4819-111-8-681
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This excerpt has been provided in the absence of an abstract.

Pneumocystis carinii pneumonia occurs with unusually high frequency in patients with human immunodeficiency virus (HIV) infection and contributes substantially to the morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS). A feature of infection with this pathogen is that disease is almost always confined to the lung, with extrapulmonary spread rarely reported. As a result, recent strategies to prevent pneumocystis infection without causing systemic toxicity have focused on aerosolized drug delivery to the lungs (1).

In 1982, a 26-year-old heterosexual male developed stage III testicular germ cell malignancy that was treated with orchiectomy and combination chemotherapy. He did well


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