0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Tumor Necrosis Factor Induces Hemorrhagic Necrosis of a Sarcoma

Paul A. Robertson, MD; Helen J. Ross, MD; and Robert A. Figlin, MD
[+] Article and Author Information

Grant Support: Supported in part by the Jonsson Comprehensive Cancer Center, University of California at Los Angeles, California, and by Genentech Inc., South San Francisco, California.

Requests for Reprints: Robert A. Figlin, MD, Department of Medicine, Division of Hematology-Oncology, University of California at Los Angeles, Louis Factor Building, Room 8-950, 700 Tiverton Avenue, Los Angeles, CA 90024.

Current Author Addresses: Drs. Figlin and Ross: University of California at Los Angeles, Medical Center, Los Angeles, CA 90024.

Dr. Robertson: Western Washington Cancer Treatment Center, Olympia, WA 98502.


Ann Intern Med. 1989;111(8):682-684. doi:10.7326/0003-4819-111-8-682
Text Size: A A A

William B. Coley, MD, a surgeon of the early 20th century, noted the regression of a soft-tissue sarcoma in the neck of a patient after a life-threatening bacterial infection. He subsequently developed Coley toxins (sterilized cultures of various gram-negative bacilli), which he administered to patients with solid tumors to reproduce the antitumor effect he had observed with severe bacterial infections. The search for a pathophysiologic explanation of this phenomenon led Carswell and colleagues (1) in 1974 to describe tumor necrosis factor. This endotoxin-induced serum factor caused necrosis within 24 hours of subcutaneously transplanted methylcholanthrene A-induced sarcoma in BCG-primed mice. The

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)