The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Diagnosis of Gastrinoma: Much Ado about Nothing?

M. Michael Wolfe, MD
[+] Article, Author, and Disclosure Information

Grant Support: Supported in part by grant RO1 DK35636 from the National Institutes of Health and grant RRO1032 from the General Research Center Program of the Division of Research Resources.

Requests for Reprints: M. Michael Wolfe, MD, Brigham and Women's Hospital, Division of Gastroenterology, 75 Francis Street, Boston, MA 02115.

Brigham and Women's Hospital
Boston, Massachusetts

Ann Intern Med. 1989;111(9):697-699. doi:10.7326/0003-4819-111-9-697
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Few disorders have attracted as much clinical interest as duodenal ulcer disease, particularly regarding pathogenesis and treatment. Many gaps remain in our understanding of the pathophysiology of this disease; however, the role of gastric acid is well established. As Karl Schwarz so eloquently stated it in 1910 (1): "Ohne saueren Magensaft, kein peptisches Geschwür": that is, "no acid, no ulcer." Although basal acid production is increased in patients with duodenal ulcer as a group (2), rates vary enormously, and approximately 50% to 60% of patients secrete normal amounts of acid in the basal state (3). Even in these latter




First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
State-of-the-art Imaging of Pancreatic Neuroendocrine Tumors. Surg Oncol Clin N Am 2016;25(2):375-400.
Surgical Management of Pancreatic Neuroendocrine Tumors. Surg Oncol Clin N Am 2016;25(2):401-21.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.