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Dietary Supplementation with Low-Dose Fish Oils Lowers Fibrinogen Levels: A Randomized, Double-Blind Controlled Study

Kenneth Radack, MD; Colleen Deck, PharmD; and Gertrude Huster, MHS
[+] Article, Author, and Disclosure Information

Grant Support: Supported in part by a grant from McNeil Consumer Products Co., Ft. Washington, Pennsylvania.

Requests for Reprints: Kenneth Radack, MD, Division of General Internal Medicine, 231 Bethesda Avenue, ML 535, Cincinnati, OH 45267.

Current Author Addresses: Drs. Radack and Deck: University of Cincinnati, Department of Internal Medicine, Division of General Internal Medicine, 231 Bethesda Avenue, ML S35, Cincinnati, OH 45267.

Ms. Gertrude Huster: University of Cincinnati, Department of Internal Medicine Clinical Research Management, ML 540, Lipid Research Clinic, Cincinnati, OH 45267.

Ann Intern Med. 1989;111(9):757-758. doi:10.7326/0003-4819-111-9-757
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This excerpt has been provided in the absence of an abstract.

Increased concentrations of plasma fibrinogen have been positively correlated with accelerated atherosclerosis in prospective epidemiologic studies (1-3) and have been shown to be a significant independent predictor for stroke (2-4) and coronary artery disease (3). In addition, raised fibrinogen levels are one of several components contributing to a "hypercoagulable state" associated with hypertriglyceridemia (5). Because of the relation between lipid metabolism, thrombosis, and atherogenesis (6), the responsiveness of fibrinogen levels to dietary interventions may have potential clinical significance. Marine n-3 fatty acid supplementation has been shown to have beneficial antiatherogenic actions related to atherosclerosis, thrombosis, and lipid metabolism (7). Although


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