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Partial Remission of Carcinoid Tumor in Response to Cyproheptadine

Stuart P. Leitner, MD; Paul Greenberg, MD; Linda A. Danieu, MD; and Richard A. Michaelson, MD
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Requests for Reprints: Stuart P. Leitner, MD, Department of Medicine, Section of Medical Oncology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ 07039.

Current Author Addresses: Drs. Leitner, Danieu, and Michaelson: Department of Medicine, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ 07039.

Dr. Greenberg: The University of Texas System Cancer Center, MD Anderson Hospital and Tumor Institute, Houston, TX 77030.

Ann Intern Med. 1989;111(9):760-761. doi:10.7326/0003-4819-111-9-760
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This excerpt has been provided in the absence of an abstract.

The malignant carcinoid syndrome of episodic flushing and diarrhea occurs in association with carcinoid tumors and an elevated urinary level of the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) (1). Treatment is often directed specifically at diminishing the tumor bulk and includes surgical resection, hepatic artery occlusion, or chemotherapy. Cyproheptadine, a serotonin and histamine antagonist, is often useful in palliating symptoms of the carcinoid syndrome but is not considered to have specific antitumor activity (2). We used cyproheptadine to treat a patient with the carcinoid syndrome. The patient had both symptomatic improvement and an objective partial remission, documented by a fall in


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