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Transfusion-Associated Acute Chagas Disease Acquired in the United States

Irene H. Grant, MD; Jonathan W.M. Gold, MD; Murray Wittner, MD, PhD; Herbert B. Tanowitz, MD; Carl Nathan, MD; Klaus Mayer, MD; Lillian Reich, MD; Norma Wollner, MD; Laurel Steinherz, MD; Fereshteh Ghavimi, MD; Richard J. O'Reilly, MD; and Donald Armstrong, MD
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Requests for Reprints: Jonathan W.M. Gold, MD, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Current Author Addresses: Dr. Grant: AIDS Unit, Bronx-Lebanon Hospital, 1192 Fulton Avenue, Bronx, NY 10456.

Drs. Gold and Armstrong: Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Drs. Wittner and Tanowitz: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

Dr. Nathan: Infectious Disease Service, Cornell University Medical College, 1300 York Avenue, New York, NY 10021.

Dr. Mayer and Dr. Reich: Blood Bank and Hematology-Lymphoma Services, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Drs. Wollner, Steinherz, Ghavimi, and O'Reilly: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Ann Intern Med. 1989;111(10):849-851. doi:10.7326/0003-4819-111-10-849
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This excerpt has been provided in the absence of an abstract.

Although a significant problem in Latin America (1), the transmission of Trypanosoma cruzi infection by transfusion has not been unequivocally documented in the United States. We report a case of severe acute transfusion-acquired Chagas disease in a child with Hodgkin disease who had never travelled to an endemic area; however, she had received platelets from an asymptomatic Bolivian immigrant who had serologic evidence of T. cruzi infection.

An 11-year-old white girl with Hodgkin disease who had been in remission since May 1987 after splenectomy, radiotherapy, and chemotherapy presented in April 1988 with a temperature of 38.3 °C. Her physical examination


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