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Transfusion-Associated Trypanosoma cruzi Infection in a Non-Endemic Area

Peter Nickerson, MD; Pamela Orr, MD; Maria-Louise Schroeder, MD; Leila Sekla, MD; and James B. Johnston, MD
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Requests for Reprints: James B. Johnston, MD, Manitoba Cancer Treatment and Research Foundation, 100 Olivia Street, Winnipeg, Manitoba, Canada R3E 0V9.

Current Author Addresses: Drs. Nickerson and Orr: University of Man itoba, Department of Medicine, Health Sciences Center, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9.

Dr. Schroeder: Canadian Red Cross, Blood Transfusion Service, Winnipeg Centre, 226 Osborne Street North, Winnipeg, Manitoba, Canada R3L 1Z3.

Dr. Sekla: Cadham Provincial Laboratory, 750 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7.

Dr. Johnston: Manitoba Cancer Treatment and Research Foundation, 100 Olivia Street, Winnipeg, Manitoba, Canada R3E 0V9.

Ann Intern Med. 1989;111(10):851-853. doi:10.7326/0003-4819-111-10-851
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This excerpt has been provided in the absence of an abstract.

Opportunistic infections have become a major cause of morbidity in the immunocompromised host. In patients with neutropenia, such infections often arise from their own indigenous flora; however, another potential mode of infection is the transmission of blood-borne organisms by transfusions. Patients with granulocytopenia who receive multiple blood products during chemotherapy are especially prone to transfusion-associated infections. We describe the first case of transfusion-associated acute Chagas disease in a nonendemic area of North America.

Case Report: In June 1986, a 1-year-old infant presented with a cerebral thrombosis and was subsequently found to have protein S deficiency. When the family was screened,


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