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Reversible Cardiomyopathy Associated with Cocaine Intoxication

Saurabh K. Chokshi, MD; Richard Moore, MD; Natesa G. Pandian, MD; and Jeffrey M. Isner, MD
[+] Article, Author, and Disclosure Information

Grant Support: Supported in part by grants HL 32747, 40518 (J.M.I.) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Requests for Reprints: Jeffrey M. Isner, MD, St. Elizabeth's Hospital, 736 Cambridge Street, Boston, MA 02135.

Current Author Addresses: Drs. Chokshi and Isner: St. Elizabeth's Hospital, 736 Cambridge Street, Boston, MA 02135.

Dr. Moore: Holmes Regional Medical Center, 1351 South Hickory Street, Melbourne, FL 32901.

Dr. Pandian: New England Medical Center, 750 Washington Street, Box 32, Boston, MA 02111.

Ann Intern Med. 1989;111(12):1039-1040. doi:10.7326/0003-4819-111-12-1039
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This excerpt has been provided in the absence of an abstract.

Cocaine intoxication typically produces a profoundly enhanced sympathomimetic state and has been temporally associated with various serious, including fatal, medical disorders. Chief among these disorders are cardiovascular complications, principally acute myocardial infarction (1). Dilated cardiomyopathy has been reported only rarely in association with cocaine abuse (2, 3). We describe a patient who developed an acutely dilated cardiomyopathy temporally related to smoking ("free-basing") the "crack" formulation of cocaine. Over 2 weeks, however, serial noninvasive studies showed reversal of her cardiomyopathy with a marked improvement in left ventricular systolic function. This patient's course was similar to that of patients with reversible catecholamine


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